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Serum under-carboxylated osteocalcin levels in women with polycystic ovary syndrome: weight-dependent relationships with endocrine and metabolic traits
Pepene Carmen E
Journal of Ovarian Research , 2013, DOI: 10.1186/1757-2215-6-4
Abstract: Background Under-carboxylated osteocalcin (ucOC), the precursor substrate of bone biomarker OC is a potent regulator of energy metabolism by promoting insulin production and adiponectin synthesis and decreasing fat stores. The aim of the present study was to point out the potential role of ucOC in the physiopathology of polycystic ovary syndrome (PCOS), a common disorder defined by the constellation of anovulation, insulinresistance, hyperinsulinemia, obesity and androgen excess. Methods In this prospective case–control investigation, 78 young premenopausal women, i.e. 52 PCOS patients and 26 age- and body mass index (BMI)-matched healthy controls, were successively enrolled. Recruitment of PCOS patients was performed according to Androgen Excess-Polycystic Ovary Syndrome (AE-PCOS) Society 2006 criteria. All study participants were subjected to clinical examination, whole-body composition assessment and measurements of serum ucOC, OC (1-49), glucose and lipids, insulin, total testosterone (TT), estradiol, sex-hormone binding globulin (SHBG), high-sensitivity C-reactive protein (Hs-CRP) and β-CrossLaps. Results BMI-stratified multivariate analysis revealed significantly higher ucOC levels in PCOS vs. controls in lean (p = 0.001) but not overweight and obese study participants (p = 0.456). Notably, a positive correlation between ucOC and TT (p = 0.018), calculated free testosterone (cFT, p = 0.028) and serum insulin (p = 0.036), respectively, was found to be confined to the lean analysis subgroup. Furthermore, in stepwise multiple regression models, β-CrossLaps and cFT were able to predict 46.71% of serum ucOC variability. (1-43/49)OC failed to be significantly associated to any PCOS trait. Conclusions Circulating ucOC concentration is related to key endocrine PCOS characteristics in a weight-dependent manner. Within the bone-pancreas loop, high ucOC may favor insulin release in lean hyperandrogenic women to compensate for impaired insulin sensitivity.
Ethinylestradiol30μg-drospirenone and metformin: could this combination improve endothelial dysfunction in polycystic ovary syndrome?
Ioana Rada Ilie, Ioan Marian, Teodora Mocan, Razvan Ilie, Lucian Mocan, Ileana Duncea, Carmen Pepene
BMC Endocrine Disorders , 2012, DOI: 10.1186/1472-6823-12-9
Abstract: 25 young women with PCOS (mean age 22.76?±?0.83 years, body mass index (BMI): 28.44?±?6.23) who completed the study were prospectively evaluated. The oral contraceptive- DRP/EE30μg (21 days/month) and metformin (1700 mg daily) were administered for 6 months to the PCOS group. Additionally, the 15 overweight and obese patients (BMI?>?25 kg/m2) were instructed in a diet of no more than 1500 cal daily. Primary outcome measures were surrogate markers of cardiovascular disease and included endothelial function, i.e. flow-mediated dilatation (FMD) on the brachial artery and endothelin-1 levels, as well as hsCRP concentrations, body composition (measured by whole-body dual-energy X-ray-absorptiometry) and insulin resistance. Variables were assessed at baseline, as well as after our medical intervention.The combination between DRP/EE30μg plus metformin combined with weight loss triggered a significant improvement in the FMD values (FMD-PCOSbasal 3.48?±?1.00 vs FMD-PCOS6 months7.43?±?1.04, p?=?0.033), as well as body composition and insulin insensitivity (p?<?0.05). Regarding hsCRP levels, there was no significant intragroup (PCOS6months – PCOSbasal) difference.A 6-month course of metformin- DRP/EE30μg (associated with weight loss) improves the endothelial dysfunction in PCOS and shows neutral effects on hsCRP concentrations as an inflammation marker. These data demand for reevaluation of the medical therapy in PCOS, particularly in women with additional metabolic and cardiovascular risk factors (ClinicalTrials.gov Identifier: NCT01459445).
Application of Statistical Methods to Assess Carbon Monoxide Pollution Variations within an Urban Area  [PDF]
Carmen Capilla
International Journal of Geosciences (IJG) , 2012, DOI: 10.4236/ijg.2012.325090
Abstract: In recent years there have been considerable new legislation and efforts by vehicle manufactures aimed at reducing pollutant emission to improve air quality in urban areas. Carbon monoxide is a major pollutant in urban areas, and in this study we analyze monthly carbon monoxide (CO) data from Valencia City, a representative Mediterranean city in terms of its structure and climatology. Temporal and spatial trends in pollution were recorded from a monitoring net- work that consisted of five monitoring sites. A multiple linear model, incorporating meteorological parameters, annual cycles, and random error due to serial correlation, was used to estimate the temporal changes in pollution. An analysis performed on the meteorologically adjusted data reveals a significant decreasing trend in CO concentrations and an annual seasonal cycle. The model parameters are estimated by applying the least-squares method. The standard error of the parameters is determined while taking into account the serial correlation in the residuals. The decreasing trend im- plies to a certain extent an improvement in the air quality of the study area. The seasonal cycle shows variations that are mainly associated with traffic and meteorological patterns. Analysis of the stochastic spatial component shows that most of the intersite covariances can be analyzed using an exponential variogram model.
Brief Note on a Scalar Quantum Field with Finite Lifetime in a Lorentz Invariant Non-Rectangular Euclidean Space  [PDF]
Carmen Tornow
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.514135
Abstract:

A not necessary rectangular Euclidean space (NoNRES) is constructed, in which one obtains a generally Lorentz invariant scalar product for the low energy sector (LES). This sector is defined for energies below the Planckian limit. If the energy is zero, the NoNRES becomes rectangular and due to the Lorentz invariance, it is applicable for the complete LES of the theory. In contrast to the usual Minkowski space the metric of the NoNRES depends on the kinetic energy of the observed quantum particles. It is assumed that this metric may be useful to derive the scattering cross-section of the corresponding quantum field theory. This assumption is related to the occurrence of divergent loop momentum integrals caused by including the infinite energy range above the Planckian limit (high energy sector or HES). Due to its energy dependence, the metric in both energy sectors differs. In the HES, it depends on the effective dimension of the NoNRES. This dependency results from fluctuations of the space-time above the Planckian limit. Even if they are not part of the theory (as they would be in quantum gravity), these fluctuations should not be ignored. The effective dimension decreases if the energy of the considered particle increases. Since this is true for the HES only, the ultraviolet divergences of loop integrals seem to vanish without distorting the results of the LES. The mechanism is illustrated by calculating the tadpole integral occurring for a simple self-interacting scalar quantum field (with the Higgs mass as example). One obtains a finite contribution for the integral and consequently for the lifetime of the scalar particle.

Human Health, Rights and Wind Turbine Deployment in Canada  [PDF]
Carmen Krogh, Brett Horner
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.55012
Abstract: Canada has ratified international conventions which recognize the individual’s right to the enjoyment of the highest attainable standard of health. Despite the adoption of these covenants governments sometimes support policies and practises which trade off individual human health with other conflicting interests. This review evaluates the individual’s right to health against government policies and practices which support wind energy deployment in Canada. Our analysis presents government documents, peer reviewed literature, and other references which support the conclusion that wind energy deployment in Canada can be expected to result in avoidable harm to human health. This harm conflicts with contemporary health and social justice principles. Governments have a responsibility to help Canadians maintain and improve their health by generating effective responses for the prevention of avoidable harm. Individuals have a right to make informed decisions about their health. Knowledge gaps and potential risks to health should be fully disclosed. Individuals should not be exposed to industrial wind turbines without their informed consent.
Effect of INTERACT on Promoting Nursing Staff’s Self-Efficacy Leading to a Reduction of Rehospitalizations from Short-Stay Care  [PDF]
Carmen U. Potter
Open Journal of Nursing (OJN) , 2019, DOI: 10.4236/ojn.2019.98063
Abstract: One in four clients discharged from an acute care facility to a skilled nursing facility (SNF) required readmission to the hospital within 30 days. Neuman, Wirtalla & Werner believe that two-third of those readmissions are avoidable. Reducing the frequency of rehospitalization from short-stay care is essential for two primary reasons: 1) Clients are exposed to hospital-acquired infections that lead to increased comorbidities, and 2) potentially avoidable hospitalization will decrease the amount of funding distributed by Medicare. The setting for the proposed change initiative was a for-profit, nondenominational SNF in Missouri. Of the 120 beds, 16 were devoted to short-stay care. The convenience sample included four registered nurses and eight licensed practical nurses who had agreed to participate in the pilot. The purposive sample included short-stay clients. Interventions implemented at the pilot skilled nursing facility are components of the validated INTERACT quality improvement program. INTERACT (Appendix A) is comprised of several tools designed to assist and guide front-line staff in early identification, assessment, communication, and documentation about acute changes in client condition. Measured results examined the effectiveness of the proposed intervention. The outcome being assessed in the project was the number of avoidable hospital admissions after implementation of the INTERACT quality initiative tools. The long-term objective for the pilot was a 2% decrease in client rehospitalizations from the short-care unit during the eight weeks of practice implementation. The clinical question for the proposed practicum project was, “For the nursing staff on a short-term rehab unit, does the implementation of an evidence-based patient evaluation tool, INTERACT lead to a reduction in avoidable hospital admissions?”.
The Epidemiology of Recurrent Violence and Its Relationship with Sentence Time in the Romanian Juvenile Prison System: A Two-Year Cohort Study  [PDF]
Carmen-Valeria Baias
Open Journal of Epidemiology (OJEpi) , 2022, DOI: 10.4236/ojepi.2022.121002
Abstract: Background: Research suggests that a small number of persistent violent offenders are responsible for a majority of prison violence and tend to behave violently to a disproportionate amount. However, literature on patterns of violence in juvenile prisoners is limited. Method: In order to explore how subjects engage in violence while incarcerated in the juvenile prison system, the authors will examine both proximal and distal predictors of violent behavior among juveniles in custody. This study adds to the current empirical research by longitudinally examining dynamic risk factors of recurrent violent behavior across a population of juvenile prisoners (Mage = 16.21; 94.8% male) in custody in the Romanian juvenile justice system, starting from their entry date until the end of the follow-up period (Me = 2 years). Results: Results from a series of repeated aggressive events survival analyses show evidence of a long-term deleterious association between pre-incarceration risk factors and poor developmental trajectory associated with violence. Adherence to destructive conduct in prison was consistently influenced by low ability to cope with the prison environment, although education level and family factors also mattered. Implications for prison professionals and forensic practitioners are presented. Conclusion: Recurring aggressive behavior is frequent for individuals who experience complex adverse experiences during childhood, suggesting that screening youths upon their admission into juvenile justice settings should include an assessment of their basic self-regulation needs. A greater focus on longitudinal studies may help improve the screening process and also follow the progress of each juvenile to warrant the efficacy of preventive programs in self-harm, according to their emerging needs.
Wolbachia induces sexual isolation in Drosophila melanogaster and Drosophila simulans  [PDF]
Ialah Gazla, Maria Carmen Carracedo
Open Journal of Genetics (OJGen) , 2011, DOI: 10.4236/ojgen.2011.12005
Abstract: Wolbachia are a group of intracellular bacteria, ma-ternally transmitted from infected females to their offspring, which affect a wide range of arthropods. Their presence is associated with Cytoplasmic Incompatibility (CI) in crosses between infected males and uninfected females and between populations carrying different strains of Wolbachia. The negative influence of Wolbachia a infection on progeny fitness in incompatible crosses can be considered a first step in the appearance of reproductive isolation between infected and uninfected individuals. In this work, we examined the possibility of assortative mating in response to Wolbachia infection, a response that evolved as an incipient mechanism of sexual isolation in the species D. melanogaster and D. simulans. We found that the females of each species could detect the presence of the bacterium in the other sex and chose to mate with males who had the same state of infection, whereas the males randomly attempted to mate with both infected and uninfected females. Thus, Wolbachia may act as an additive factor influencing sexual isolation in Drosophila populations and may play a role in speciation events.
Nanomaterials for Drugs Delivery  [PDF]
Francisco Márquez, Carmen Morant
Soft Nanoscience Letters (SNL) , 2014, DOI: 10.4236/snl.2014.43007
Abstract:

As expected for years, nanotechnology has revolutionized engineering, biology, chemistry, physics and medicine of today. These disciplines are evolving thanks to the ongoing development of new materials and applications. Nanomedicine, as application of nanotechnology in the field of health care, has undergone unprecedented development. Some of these changes have real applications as, for example, the use of nanoparticles in MRI imaging, in hyperthermia, in immunotherapy, or to improve the bioavailability of drugs, among others [1]-[3].

When a drug is administered to a patient, the blood distributes it throughout the body. In the case of very localized diseases (i.e. tumors), only a small fraction of the drug reaches the target. Chemotherapy is one of the most aggressive treatment options used in some types of cancer, and is usually administered intravenously. In this type of therapy, the drug circulates throughout the body, reaching and destroying healthy and cancerous tissues, producing side effects throughout the body, sometimes with serious consequences for the health of the patient (nephrotoxicity, cardiotoxicity, peripheral neuropathy, anemia, etc.). Among the many applications of nanotechnology, the fabrication of nanostructures capable of safely transporting these drugs is seen as a strategy for reducing these side effects. Nanoparticles are able to carry and release the drug in the right place and with the required dose, greatly reducing the problems associated with direct treatment with these drugs.

In recent years, there have been continuous improvements in the design and development of new tailor-made drug delivery systems [4], including hollow magnetic nanoparticles, liposomal structures, dendrimers, nanoporous silicon, etc. These structures can be obtained with different molecular weights (in the case of polymers), structures, shapes, and even with the appropriate functional groups for interaction at the desired positions. However, a great effort is still required to solve many of the current problems [5], including toxicity, aggregation, solubility and stability in the human body, physiological processes of elimination, identification of targets by highly specific receptors, controlled drug release over time, etc.

Nanomaterials for Sensor Applications  [PDF]
Francisco Márquez, Carmen Morant
Soft Nanoscience Letters (SNL) , 2015, DOI: 10.4236/snl.2015.51001
Abstract: Recently, a large part of the advances in nanotechnology have been directed towards the development of high-speed electronics, more efficient catalysts, and sensors. This latter group of applications has great relevance and unprecedented development potential for the coming years.So far, some of the main objectives for the development of sensors have focused on making more sensitive, effective and specific sensing devices.The improvement of these systems and the increase of specificity are clearly associated with a decrease in size of the components, which can lead to obtaining more rapid action, almost in real time. Nanomaterials currently used in sensor development include a long list of nanostructured systems, as for example: metal nanotubes, nanowires, nanofibers, nanocomposites, nanorods, nanoparticles, nanostructured polymers, and different allotropes of carbon as carbon nanotubes, graphene or fullerenes, among others.
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